Endocrine Abstracts

Background: Few studies have scrutinized the spectrum of symptoms in subclinical hypothyroidism.Methods: From three DanThyr cross-sectional surveys performed in the period 1997 to 2005, a total of 8,903 volunteers participated in a comprehensive investigation including blood samples and questionnaires on previous diseases, smoking habits, alcohol intake, and education. From the three surveys we included patients with unknown subclinical hypothyroidism (<...

Objectives: Hypothyroid patients report a diversity of symptoms at disease presentation. We studied how useful symptoms are to predict hypothyroidism, and if this may vary between subgroups of patients.Methods: Patients newly diagnosed with overt autoimmune hypothyroidism (n=140) were prospectively identified in a population by linkage to diagnostic laboratory databases, and we concomitantly enrolled individually sex and age-region matched contr...

Introduction: Autoimmune thyroid disease is associated with other autoimmune diseases. However, most studies are register-based cohort studies or investigate selected patient populations. In a large national cross-sectional population-based study, we investigated positivity of thyroid peroxidase- or thyroglobulin-antibodies (TPOAbs or TgAbs) in association with non-thyroidal autoimmune disease.Methods: As part of The Danish Investigation of Iodine Intake...

Objectives: Hyperthyroidism in pregnant women is a clinical concern, and it is important to surveil any change in the occurrence of hyperthyroidism within the pregnant population specifically, especially when a mandatory iodine fortification (IF) program is implemented as it was in Denmark in the year 2000. This longitudinal study aimed to investigate any change in the use of antithyroid drugs (ATD) for the treatment of hyperthyroidism in Danish pregnant women during a 20-year...

Objectives: Iodine intake affects the risk of thyroid disorders. This study aimed to calculate the overall incidence of thyroid dysfunctions and structural abnormalities in the Faroe Islands and to describe the relation to sex and age.Methods: We performed a nationwide, register-based study covering all 54,000 inhabitants of the Faroe Islands between 2006 and 2018. Cases were identified and classified by thyroid dysfunction using redeemed prescriptions o...

Objectives: One of the risk-based screening criteria for thyroid disease in pregnancy is previous abnormal thyroid function or thyroid autoantibody-positivity. We speculated on the frequency and results of thyroid function testing in women of fertile age as part of routine care before and after a pregnancy.Methods: The North Denmark Region Pregnancy Cohort includes retrospective assessment of thyroid function and thyroid autoantibodies (ADVIA Centaur XPT...

Objectives: Thyroid disease in women of reproductive age is predominantly of autoimmune origin, and thyroid peroxidase antibodies (TPO-Ab) as well as thyroglobulin antibodies (Tg-Ab) are key markers of autoimmune hypothyroidism. Adding to this, much focus in pregnancy is on euthyroid women who are positive for thyroid autoantibodies. The observational findings are diverse, and evidence to substantiate the applied cut-offs for definition of thyroid autoantibody-positivity in ea...